1 00:00:04,630 --> 00:00:02,149 the bones in our bodies are alive 2 00:00:05,990 --> 00:00:04,640 growing and changing all the time 3 00:00:07,909 --> 00:00:06,000 our bones are composed of different 4 00:00:10,230 --> 00:00:07,919 layers the outer surface of bone is 5 00:00:11,910 --> 00:00:10,240 called cortical bone this is the smooth 6 00:00:13,749 --> 00:00:11,920 hard part of the bone that we can see 7 00:00:15,669 --> 00:00:13,759 when we look at a skeleton inside the 8 00:00:17,430 --> 00:00:15,679 cortical bone is the trabecular bone 9 00:00:20,630 --> 00:00:17,440 this type of bone looks like a sponge 10 00:00:22,390 --> 00:00:20,640 and helps to protect the bone marrow 11 00:00:25,109 --> 00:00:22,400 the constant process of bones growing 12 00:00:26,870 --> 00:00:25,119 and changing is known as bone remodeling 13 00:00:28,950 --> 00:00:26,880 this process is carried out by specific 14 00:00:31,109 --> 00:00:28,960 cells in our bones cells called 15 00:00:33,110 --> 00:00:31,119 osteoclasts have the role of breaking 16 00:00:35,030 --> 00:00:33,120 down our bone and removing any parts 17 00:00:36,470 --> 00:00:35,040 that need replacing 18 00:00:38,950 --> 00:00:36,480 at the same time cells called 19 00:00:40,790 --> 00:00:38,960 osteoblasts have the job of making new 20 00:00:42,869 --> 00:00:40,800 bone and helping to repair any parts of 21 00:00:45,190 --> 00:00:42,879 the bone that have been damaged 22 00:00:47,110 --> 00:00:45,200 on earth in healthy individuals this 23 00:00:49,270 --> 00:00:47,120 process is normally balanced so that the 24 00:00:53,910 --> 00:00:49,280 same amount of bone is made and broken 25 00:00:57,990 --> 00:00:55,990 in space astronauts are exposed to lower 26 00:00:59,510 --> 00:00:58,000 levels of gravity than on earth this 27 00:01:01,029 --> 00:00:59,520 means that they have less mechanical 28 00:01:02,069 --> 00:01:01,039 stress put on their bones as they move 29 00:01:03,670 --> 00:01:02,079 around 30 00:01:05,189 --> 00:01:03,680 scientists believe that the bones 31 00:01:06,870 --> 00:01:05,199 naturally try to adapt to this new 32 00:01:08,230 --> 00:01:06,880 environment by increasing the rate that 33 00:01:10,870 --> 00:01:08,240 the bone is broken down by the 34 00:01:12,630 --> 00:01:10,880 osteoclasts meanwhile bone formation 35 00:01:14,230 --> 00:01:12,640 continues to occur at the same rate as 36 00:01:15,910 --> 00:01:14,240 it does on earth 37 00:01:17,590 --> 00:01:15,920 the result is an imbalance in bone 38 00:01:21,270 --> 00:01:17,600 remodeling which leads to an overall 39 00:01:23,030 --> 00:01:21,280 decrease in bone mineral density 40 00:01:24,469 --> 00:01:23,040 while in space astronauts can manage 41 00:01:26,550 --> 00:01:24,479 with lower bone density but when they 42 00:01:28,630 --> 00:01:26,560 return their bones are less able to cope 43 00:01:30,950 --> 00:01:28,640 with earth's gravity this increases the 44 00:01:32,310 --> 00:01:30,960 risk of fracture and injury scientists 45 00:01:34,550 --> 00:01:32,320 use many different tests to measure the 46 00:01:36,710 --> 00:01:34,560 density of the astronauts bones results 47 00:01:38,870 --> 00:01:36,720 show that the astronauts while in space 48 00:01:41,190 --> 00:01:38,880 lose bone in a similar pattern to people 49 00:01:43,190 --> 00:01:41,200 on earth who suffer from osteoporosis 50 00:01:46,310 --> 00:01:43,200 but the astronauts lose it at a much 51 00:01:49,830 --> 00:01:48,069 scientists have found that exercise when 52 00:01:52,310 --> 00:01:49,840 combined with good nutrition and 53 00:01:53,990 --> 00:01:52,320 increased vitamin d intake is able to 54 00:01:55,749 --> 00:01:54,000 preserve some of the bone that was 55 00:01:57,910 --> 00:01:55,759 previously being lost 56 00:01:59,749 --> 00:01:57,920 since 2008 astronauts have been able to 57 00:02:02,069 --> 00:01:59,759 use a new exercise machine called the 58 00:02:04,550 --> 00:02:02,079 advanced resistive exercise device or a 59 00:02:06,870 --> 00:02:04,560 red it is thought that this increase in 60 00:02:08,309 --> 00:02:06,880 force triggers the formation of new bone 61 00:02:10,550 --> 00:02:08,319 bringing more balance to the bone 62 00:02:12,229 --> 00:02:10,560 remodeling process and allowing the bone 63 00:02:15,990 --> 00:02:12,239 density to stay at roughly the same 64 00:02:17,510 --> 00:02:16,000 level as it was before the space flight 65 00:02:19,589 --> 00:02:17,520 it is a significant achievement to be 66 00:02:21,190 --> 00:02:19,599 able to maintain bone density in space 67 00:02:22,869 --> 00:02:21,200 but more experiments need to be carried 68 00:02:25,030 --> 00:02:22,879 out to see whether the new bone which is 69 00:02:26,869 --> 00:02:25,040 formed in space has the same structure 70 00:02:28,949 --> 00:02:26,879 and strength as new bone which is formed 71 00:02:30,949 --> 00:02:28,959 on earth understanding bone loss 72 00:02:32,949 --> 00:02:30,959 associated with microgravity may lead to 73 00:02:34,710 --> 00:02:32,959 better preventive care or therapeutic 74 00:02:36,869 --> 00:02:34,720 treatments for people on earth suffering 75 00:02:39,670 --> 00:02:36,879 bone loss as a result of bone diseases